Neurodrine manufacturers cite 35 studies on Neurodrine.com that validate the effects of the supplement and their ingredients and dosages. We'll look at some of this evidence below to determine if Neurodrine really works or if it's yet another overrated nootropic supplement backed by little real evidence.
First, Advanced Biohealth cites this 2017 study of Huperzine A. In that study, researchers found that Huperzine A relieved neuroinflammation and oxidative stress by improving cognitive function after repeated traumatic brain injury. The researchers gave the participants 1 mg/kg of Huperzine A per day or about 100 mg of Huperzine A per day for a 160-pound person. Although Neurodrine contains a fraction of that dose (around 10 mcg), other studies have shown that huperzine A can provide significant cognitive benefits even at doses up to 10 mg. However, 10 mcg is an extremely low dose of Huperzine A and may not provide significant benefit at such a low dose.
Some people take St. John's wort every day for cognition and brainpower. In this 2009 study, researchers analyzed the effects of St. John's wort on brainpower. The researchers found that St. John's wort seemed effective for cognitive benefits, although it did cross the blood-brain barrier in humans and animals. However, other studies have linked St. John's wort to depression relief and other short-term benefits.
Phosphatidylserine is one of the most popular nootropic supplement ingredients available today. In this 2015 study, researchers evaluated the role of phosphatidylserine in the human brain. The researchers found that phosphatidylserine was "necessary for the health of nerve cell membranes and myelin." The researchers also found that phosphatidylserine levels naturally decline with aging. By taking a phosphatidylserine supplement with 300 mg to 800 mg of phosphatidylserine per day, you could support brain power and overall cognition. Neurodrine contains 125 mg of phosphatidylserine per serving.
Vinpocetine is another popular nootropic supplement that has been shown to work even in small dosages. Each serving of Neurodrine contains 2 mg of vinpocetine, which sounds like a small dose but is enough to provide significant cognitive benefits. In this 2019 study, for example, researchers looked at dozens of evidence on vinpocetine and how it works. The researchers concluded that vinpocetine was linked to anti-inflammatory effects, improved cognition and memory, and other benefits.
L-glutamine is best known for its effects as a pre and post-workout supplement. Many bodybuilders, for example, take glutamine to boost recovery. However, growing research has validated the use of L-glutamine for brain health. In this 2010 study, for example, researchers showed that glutamine plays a role in neurotransmission. Neurotransmitters, the cells in the brain that allow the brain to communicate, need amino acids such as glutamine to function properly. By taking a glutamine supplement, you could support cognitive health in a number of ways.
Advanced Biohealth is particularly confident in the benefits of N-acetyl L-carnitine, or NALCAR. The company says NALCAR has been shown to increase brain metabolism, deliver nutrients to the mitochondria, and provide other significant benefits. Mitochondria are the powerhouses of brain cells. By giving your mitochondria the fuel they need, you can presumably increase cognitive energy.
According to Advanced Biohealth, the NALCAR in Neurodrine will also eliminate waste by cleaning up the toxic byproducts of energy production from cells. Instead of producing dirty energy that pollutes the neurons in the brain, the mitochondria will produce clean energy for better overall brain function.
Overall, Neurodrine has not completed clinical studies, nor have Advanced Biohealth or Alan Walker published the formula in a peer-reviewed journal. However, brain-boosting supplements contain a mix of ingredients that could support cognition, brainpower, and overall mental strength in a number of ways, according to scientific evidence.
